SENCER-ISE supports diverse cross-sector partnerships between places of informal learning (including science museums, science centers, nature centers, a zoo, and national parks) and higher education institutions that collaborate on civic engagement projects.

The individual SENCER-ISE partnerships seek to 1) bridge the known cultural gaps between the informal and formal sectors, 2) bring a range of strengths to a common task, 3) build longer term relationships, and 4) involve learns of all ages, who take part in activities that center on STEM and civic issues, many focused on local concerns.